Second-order spatial summation in amblyopia

Amblyopes show bilateral loss of sensitivity for second-order (contrast defined) stimuli that can be further suppressed by flanking second-order stimuli (whereas flanks facilitate sensitivity in normal observers). The suppressive flank effect in amblyopes might be explained by abnormal pooling of second-order contrast across visual space. In this study, we investigate whether amblyopes show abnormal second-order spatial summation by measuring contrast detection thresholds for 1c/deg modulations of random noise (stimuli 1-12 cycles) in amblyopic observers, strabismic observers with no visual acuity loss, and normal (control) observers. Non-control observers showed substantial bilateral loss of sensitivity relative to the control observers, as expected. However, all observers showed essentially equal second-order spatial summation: contrast detection threshold decreased with approximately the square root of the number of cycles, and then became independent of size at 6-8 cycles (similar asymptotes). We conclude that the pooling of second-order contrast across visual space is unaffected by amblyopia.